BMJ 2002;325:785-786 ( 12 October )

Editorials

Surgery for primary hyperparathyroidism

Patients continue to be at increased risk of renal stone disease 10 years after surgery

Papers p 807

The first 150 words of the full text of this article appear below.

A decade ago, Broadus reviewed the historical data on the clinical manifestations of primary hyperparathyroidism.1 Previously renal stone disease was recognised to be a far more frequent complication than bone disease---about half the patients with primary hyperparathyroidism in clinical series published through the 1970s presented with renal stones.1 Modern diagnostic tools for recognising hypercalcaemia and serum concentrations of parathyroid hormone have had a dramatic impact on the frequency with which primary hyperparathyroidism is diagnosed, especially in older people with non-specific symptoms of the disease. Renal stone disease is considered a less frequent complication by some investigators, 2 3 although others have reported that up to 75% of patients undergoing surgical treatment for primary hyperparathyroidism present with nephrolithiasis.4 Now, a study by Mollerup et al in this issue shows that patients with primary hyperparathyroidism not only have a greater risk of renal stone disease but that this risk persists for 10 years after . . . [Full text of this article]


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Relevant Article

Risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: controlled retrospective follow up study
Charlotte L Mollerup, Peter Vestergaard, Vibe Gedsø Frøkjær, Leif Mosekilde, Peer Christiansen, and Mogens Blichert-Toft
BMJ 2002 325: 807. [Abstract] [Full Text] [PDF]

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Persistence of high urinary excretion of calcium in patients with renal stones operated for pHPT.
Vibe G. Frøkjær
bmj.com, 11 Oct 2002 [Full text]



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