For and against: No consent should be needed for using leftover body material for scientific purposes * For * Against

doi:10.1136/bmj.325.7365.648

BMJ 2002;325:648-651 ( 21 September )

Education and debate

For and against

No consent should be needed for using leftover body material for scientific purposes

For

Against

No consent should be needed for using leftover body material for scientific purposes

Papers p 634

The first 150 words of the full text of this article appear below.

In Britain the Alder Hey scandal brought to public attention the fact that body material left over after diagnostic proceduresmay be used for teaching and research $---$ usually without the patient'sconsent. Paul van Diest argues that, Alder Hey apart, this practicehas not caused protest, mainly because the alternative would beto discard the material. He argues that self determination isnot an overriding principle in the case of material that is otherwisethrown away. Julian Savulescu, however, cites cases where patientshave felt "used" when their tissue has been kept without theirconsent. He argues that the best way to retain tissue for researchis through educating and encouraging people to donate their redundanttissues, not by taking them without their knowledge

Paul J van Diest, professor of oncological pathology.

Department of Pathology, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, Netherlands

pj.vandiest@vumc.nl

During diagnostic procedures larger samples of body fluids and tissues are usually collected than strictly necessary for primarytesting, "just in case." The big advantage is, . . . [Full text of this article]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

StumbleUpon Add to Technorati

Technorati What's this?

Relevant Articles

Why should we seek consent for using left over tissue samples?
BMJ 2002 325: 0. [Full Text]

Consent for research on stored body samples
BMJ 2002 325: 0. [Full Text] [PDF]

Informed consent for genetic research on blood stored for more than a decade: a population based study: Birgitta Stegmayr and Kjell Asplund
BMJ 2002 325: 634-635. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

van der Groep, P, van Diest, P J, Menko, F H, Bart, J, de Vries, E G E, van der Wall, E (2009). Molecular profile of ductal carcinoma in situ of the breast in BRCA1 and BRCA2 germline mutation carriers. J. Clin. Pathol. 62: 926-930 [Abstract] [Full text]
Vermeulen, E, Schmidt, M K, Aaronson, N K, Kuenen, M, van der Valk, P, Sietses, C, van den Tol, P, van Leeuwen, F E (2009). Opt-out plus, the patients' choice: preferences of cancer patients concerning information and consent regimen for future research with biological samples archived in the context of treatment. J. Clin. Pathol. 62: 275-278 [Abstract] [Full text]
Treweek, S., Doney, A., Leiman, D. (2009). Public attitudes to the storage of blood left over from routine general practice tests and its use in research. J Health Serv Res Policy 14: 13-19 [Abstract] [Full text]
Gort, E. H., Suijkerbuijk, K. P.M., Roothaan, S. M., Raman, V., Vooijs, M., van der Wall, E., van Diest, P. J. (2008). Methylation of the TWIST1 Promoter, TWIST1 mRNA Levels, and Immunohistochemical Expression of TWIST1 in Breast Cancer. Cancer Epidemiol. Biomarkers Prev. 17: 3325-3330 [Abstract] [Full text]
Suijkerbuijk, K. P. M., Fackler, M. J., Sukumar, S., van Gils, C. H., van Laar, T., van der Wall, E., Vooijs, M., van Diest, P. J. (2008). Methylation is less abundant in BRCA1-associated compared with sporadic breast cancer. Ann Oncol 19: 1870-1874 [Abstract] [Full text]
Boone, J, Kate, F J W T., Offerhaus, G J A, van Diest, P J, Rinkes, I H M B., van Hillegersberg, R (2008). mTOR in squamous cell carcinoma of the oesophagus: a potential target for molecular therapy?. J. Clin. Pathol. 61: 909-913 [Abstract] [Full text]
van Hattem, W A, Brosens, L A A, de Leng, W W J, Morsink, F H, Lens, S, Carvalho, R, Giardiello, F M, Offerhaus, G J A (2008). Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis. Gut 57: 623-627 [Abstract] [Full text]
Andanda, P A (2008). Human-tissue-related inventions: ownership and intellectual property rights in international collaborative research in developing countries. J. Med. Ethics 34: 171-179 [Abstract] [Full text]
Horree, N, van Diest, P J, van der Groep, P, Sie-Go, D M D S, Heintz, A P M (2008). Progressive derailment of cell cycle regulators in endometrial carcinogenesis. J. Clin. Pathol. 61: 36-42 [Abstract] [Full text]
Wendler, D. (2006). One-time general consent for research on biological samples: is it compatible with the health insurance portability and accountability act?. Arch Intern Med 166: 1449-1452 [Full text]
van der Groep, P, Bouter, A, van der Zanden, R, Siccama, I, Menko, F H, Gille, J J P, van Kalken, C, van der Wall, E, Verheijen, R H M, van Diest, P J (2006). Distinction between hereditary and sporadic breast cancer on the basis of clinicopathological data. J. Clin. Pathol. 59: 611-617 [Abstract] [Full text]
Kapp, M B (2006). Ethical and legal issues in research involving human subjects: do you want a piece of me?. J. Clin. Pathol. 59: 335-339 [Abstract] [Full text]
Hoeyer, K., Olofsson, B.-O., Mjorndal, T., Lynoe, N. (2005). The Ethics of Research Using Biobanks: Reason to Question the Importance Attributed to Informed Consent. Arch Intern Med 165: 97-100 [Abstract] [Full text]
Hooft, L., van der Veldt, A. A. M., van Diest, P. J., Hoekstra, O. S., Berkhof, J., Teule, G. J. J., Molthoff, C. F. M. (2005). [18F]Fluorodeoxyglucose Uptake in Recurrent Thyroid Cancer Is Related to Hexokinase I Expression in the Primary Tumor. J. Clin. Endocrinol. Metab. 90: 328-334 [Abstract] [Full text]
Furness, P N, Nicholson, M L (2004). Obtaining explicit consent for the use of archival tissue samples: practical issues. J. Med. Ethics 30: 561-564 [Abstract] [Full text]
Hoeyer, K., Olofsson, B.-O., Mjorndal, T., Lynoe, N. (2004). Informed consent and biobanks: a population-based study of attitudes towards tissue donation for genetic research. Scand J Public Health 32: 224-229 [Abstract]
Goodson, M L, Vernon, B G (2004). A study of public opinion on the use of tissue samples from living subjects for clinical research. J. Clin. Pathol. 57: 135-138 [Abstract] [Full text]
Furness, P. (2003). Consent to using human tissue. BMJ 327: 759-760 [Full text]
van Diest, P J, Lopes Cardoso, N W J, Niesing, J (2003). Cadaveric tissue donation: a pathologist's perspective. J. Med. Ethics 29: 135-136 [Full text]

Rapid Responses:

Read all Rapid Responses

More reasons for asking consent:: Caroline (I don't have a middle initial) Richmond, et al.
bmj.com, 20 Sep 2002 [Full text]
Use of archival diagnostic tissues: Adrian K Charles
bmj.com, 20 Sep 2002 [Full text]
Consent exception: Carlos E. Poli de Figueiredo
bmj.com, 21 Sep 2002 [Full text]
My views.: Roger Lee
bmj.com, 21 Sep 2002 [Full text]
Who's body is it anyway?: Kevin J. Elks, et al.
bmj.com, 21 Sep 2002 [Full text]
Propective consent is impossible: Terry J Hamblin
bmj.com, 21 Sep 2002 [Full text]
Why not inform and invite objections?: Peter N Furness, et al.
bmj.com, 23 Sep 2002 [Full text]
Illogical: Ann Tweddel
bmj.com, 23 Sep 2002 [Full text]
Re: Use of archival diagnostic tissues: Paul J van Diest
bmj.com, 23 Sep 2002 [Full text]
Re: Why not inform and invite objections?: Lizanne Duckworth
bmj.com, 23 Sep 2002 [Full text]
inform, educate and enthuse: Simon Knowles
bmj.com, 24 Sep 2002 [Full text]
Am I the One?: E Parsons
bmj.com, 25 Sep 2002 [Full text]
Wasting waste tissue: a moral choice?: Elliott Foucar
bmj.com, 25 Sep 2002 [Full text]
Cultural Sensitivity: Barry D Mahon
bmj.com, 26 Sep 2002 [Full text]
Greed induced herd instincts: Taliesin J Golesworthy
bmj.com, 27 Sep 2002 [Full text]
Serum is body material too: Daniela Zauli, et al.
bmj.com, 27 Sep 2002 [Full text]
'Heart' versus 'head'.: Martin J Duckworth
bmj.com, 27 Sep 2002 [Full text]
Re: Re: Why not inform and invite objections?: Peter N. Furness
bmj.com, 2 Oct 2002 [Full text]
Patients do not like surprises like Mr. Moore got in 1980: vijay Rajput, et al.
bmj.com, 17 Oct 2002 [Full text]
Benefits from using leftover tissue without consent: Peter Horby, et al.
bmj.com, 23 Oct 2002 [Full text]
The dog-in-the-manger generation: (Dr) Trevor LP Watts
bmj.com, 24 Oct 2002 [Full text]