Hormone replacement therapy

doi:10.1136/bmj.325.7356.113

BMJ 2002;325:113-114 ( 20 July )

Editorials

Hormone replacement therapy

Findings of women's health initiative trial need not alarm users

The first 150 words of the full text of this article appear below.

Observational studies have suggested a major health benefit of postmenopausal hormone replacement therapy, including reductionsin coronary heart disease, osteoporotic fractures, and colorectalcancer. Such studies have also suggested an increased risk forbreast cancer and possibly stroke. Critics have said that thebenefits, but not the risks, may simply reflect a healthy userbias and have demanded randomised trials. The women's health initiativeis a randomised trial of these health outcomes to assess risksand benefits of intervention strategies in a postmenopausal population.The trial has shown harm for cardiovascular diseases, includingcoronary heart disease (the primary outcome) and stroke, althoughit showed benefits for hip fractures and bowel cancer. The relativerisks for invasive breast cancer, coronary heart disease, andstroke were increased, although the absolute risks were very small.The findings may not be the same for types of hormone replacementtherapy other than those used in . . . [Full text of this article]

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Rapid Responses:

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Strange are the Ways of Nature.: BM HEGDE
bmj.com, 21 Jul 2002 [Full text]
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