BMJ 2002;325:61 ( 13 July )

News

Hormone trial for disease prevention stopped early

Janice Hopkins Tanne, New York
The first 150 words of the full text of this article appear below.

A US randomised, placebo controlled, double blind trial to evaluate oestrogen and progestogen in postmenopausal women was stopped early by the Women's Health Initiative because health risks exceeded health benefits by a small margin.

It is the first trial to examine whether continuous oestrogen plus progestogen has a favourable or unfavourable effect on coronary heart disease and overall risks and benefits in healthy women.

JAMA has already posted the article on its website (www.jama.com). The article will then be published in the 17 July issue together with an editorial that says, "do not use estrogen/progestin to prevent chronic disease" (JAMA 2002;288:321-33, 366-8).

Lead author Dr Jacques Rossouw, acting director of the study for the National Heart, Lung, and Blood Institute, cautioned, "This is not an urgent situation like a drug recall. The average risk to the individual woman is one tenth of 1% per year for breast cancer . . . [Full text of this article]
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This article has been cited by other articles:

  • Tanne, J. H. (2004). Oestrogen doesn't protect mental function in older women. BMJ 328: 1514-1514 [Full text]  
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  • Koch, K. (2003). Schering uses German medical association to promote HRT. BMJ 326: 1161-1161 [Full text]  
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Rapid Responses:

Read all Rapid Responses

Links to HRT information on MCA website
Jane Viner, et al.
bmj.com, 12 Jul 2002 [Full text]
Stopping Hormone replacement therapy
Ellen C G Grant
bmj.com, 14 Jul 2002 [Full text]
HRT and The Breast
J Michael Dixon
bmj.com, 15 Jul 2002 [Full text]
Lets try not to be smug
Peter R Bradley
bmj.com, 17 Jul 2002 [Full text]
BEFORE AND AFTER 9th of JULY
Tayfun Bagis, et al.
bmj.com, 17 Jul 2002 [Full text]
Increase in breast cancer was not statistically significant
Adam Jacobs
bmj.com, 19 Jul 2002 [Full text]
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