Growth hormone in growth hormone deficiency

doi:10.1136/bmj.325.7355.58

BMJ 2002;325:58-59 ( 13 July )

Editorials

Growth hormone in growth hormone deficiency

Start treatment early and give it for long enough

Papers p 70

The first 150 words of the full text of this article appear below.

With the advent of an unlimited supply of recombinant DNA growth hormone some 15 years ago endocrinologists and paediatricianshoped that the major goal in treating children with growth hormonedeficiency $---$ that is, a near normal adult height $---$ would finally beachievable.

Carel and colleagues report in this issue the adult height after "long term" recombinant growth hormone treatment for idiopathicisolated growth hormone deficiency.¹ The investigators wereable to analyse entry data on all French children with growthhormone deficiency whose treatment started between 1987 and 1992and stopped in 1996 under the auspices of the French nationalprogramme, Association France Hypophyse. They then were able torecord adult heights for 76% of these patients. Gain in heightwas on average a disappointing 1.1 (0.9 SD). Overall, the treatmentof a child for about three years (certainly not "long term") wasassociated with an estimated gain in height of only 4.2 cm. Facedwith these . . . [Full text of this article]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

StumbleUpon Add to Technorati

Technorati What's this?

Relevant Articles

Growth hormone in growth hormone deficiency: Jean-Claude Carel, Emmanuel Ecosse, Joël Coste, Sandro Loche, Mohamad Maghnie, and Marco Cappa
BMJ 2002 325: 1037. [Extract] [Full Text]

Growth hormone is overused
BMJ 2002 325: 0. [Full Text]

Website of the week: Growth hormone: Navin Chohan
BMJ 2002 325: 110. [Full Text]

Adult height after long term treatment with recombinant growth hormone for idiopathic isolated growth hormone deficiency: observational follow up study of the French population based registry: Jean-Claude Carel, Emmanuel Ecosse, Marc Nicolino, Maïté Tauber, Juliane Leger, Sylvie Cabrol, Irène Bastié-Sigeac, Jean-Louis Chaussain, and Joël Coste
BMJ 2002 325: 70. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

Carel, J.-C., Ecosse, E., Coste, J., Loche, S., Maghnie, M., Cappa, M. (2002). Growth hormone in growth hormone deficiency. BMJ 325: 1037-1037 [Full text]
(2002). Results of Long-Term Growth Hormone Treatment. JWatch General 2002: 6-6 [Full text]