BMJ 2002;324:588-591 ( 9 March )

Clinical review

Science, medicine, and the future

Microdialysis

Markus Müller, associate professor. 

Department of Clinical Pharmacology, Vienna University School of Medicine, Vienna General Hospital, Allgemeines Krankenhaus-AKH, Währinger Gürtel 18-20, A-1090 Vienna, Austria

markus.mueller@univie.ac.at

The first 150 words of the full text of this article appear below.

Monitoring tissue chemistry in patients by microdialysis is likely to become routine in clinical practice

Many diagnostic and therapeutic decisions in medical practice are based on measuring blood concentrations of endogenous molecules. Yet most biochemical and pharmacological events take place in the tissues. Assessing tissue chemistry should theoretically provide more accurate data, and this can now be achieved relatively cheaply and minimally invasively with microdialysis. This review describes the technique of microdialysis and its application in clinical research, drug monitoring, and drug development. It also discusses how, in the future, measurement of tissue rather than blood chemistry may become the standard for some clinical investigations.

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	Methods

This article is based on 10 years of personal experience of using microdialysis to monitor tissue chemistry in various clinical settings and on a comprehensive study of the literature. A Medline search at the time of writing provided 1020 articles for "microdialysis and human" and 7277 articles for . . . [Full text of this article]

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