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Scott M Montgomery Enheten för
Klinisk Epidemiologi, Karolinska Sjukhuset L1:00, SE-171 76, Stockholm,
Sweden Correspondence to: Dr
Montgomery Scott.Montgomery@medks.ki.se
| The first 150 words of the full text of this article appear below. |
Exposures in utero may increase the risk of type 2 diabetes.
1 2
We tested the hypothesis that
maternal smoking during pregnancy increases both the risk of early
onset type 2 diabetes3 and non-diabetic obesity in offspring.
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Methods and results |
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We used data are from the British National Child Development Study (NCDS),4 based on the Perinatal Mortality Survey (PMS) of about 17 000 births from 3 to 9 March 1958. The first sweep of the study in 1965 had 15 396 responses. The cohort remained generally representative at age 33 years (n=11 359).5 Missing data reduced the proportion in social class V from 6.4% in sweep 1 to 5.3%. Ethics committee approval was obtained for research involving medical examinations, and cohort members signed consent forms at age 33 years allowing access to medical records.
Medical examinations and record reviews by local authority medical
officers were conducted at ages 7 and 16 years. Children with
incomplete or equivocal information on diabetes or with a recorded
onset before the age of
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