BMJ 2001;323:1033-1034 ( 3 November )

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Prenatal growth and risk of occlusive and haemorrhagic stroke in Swedish men and women born 1915-29: historical cohort study

E Hyppönen, research fellow ^a, D A Leon, professor of epidemiology ^b, M G Kenward, professor of biostatistics ^b, H Lithell, professor of geriatrics ^c. 

^a Department of Paediatric Epidemiology and Biostatistics, Institute of Child Health, London WC1N 1EH, ^b Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, ^c Department of Public Health and Caring Sciences, Geriatrics, University of Uppsala, Uppsala SE-751 25, Sweden

Correspondence to: D A Leon david.leon@lshtm.ac.uk

The first 150 words of the full text of this article appear below.

Evidence for an inverse association of impaired fetal growth with stroke is less securely established than that with coronary heart disease. Even less is known about the association of fetal growth with occlusive stroke and haemorrhagic stroke.

	Participants, methods, and results

The cohort comprises all 14 611 births in the Uppsala Academic Hospital between 1915 and 1929.¹ Socioeconomic circumstances and neonatal characteristics, including gestational age (number of completed weeks since last menstrual period), were available for 96% of the subjects from hospital records and follow up is 98% complete. Analyses were restricted to singletons born at 30-45 weeks' gestation for whom information was available in the 1960 and 1970 censuses. Data on occurrence of first stroke were obtained from the Swedish national hospital discharge register² and from the national cause of death register. Two subtypes of stroke were definedhaemorrhagic (ICD-8 (international classification of diseases, 8th revision) 430-431; ICD-9 430-432) and occlusive (ICD-8 432-436; ICD-9 433-436). Each . . . [Full text of this article]

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