Terminology used in article on cloning was incorrect

doi:10.1136/bmj.323.7316.804

BMJ 2001;323:804 ( 6 October )

Letters

Terminology used in article on cloning was incorrect

The first 150 words of the full text of this article appear below.

EDITOR $---$ The myth that stem cells developed by cloning will be genetically similar to the adult needs to be exposed. Scientifically,the statements in the box in Mayor's news article are wrong.¹The Donaldson report (page 23, para 2.28) states "animals bornfrom cell nuclear replacement are not exactly identical to theanimal cell whose cell nucleus was used in the process. They inheritmitochondrial DNA (contained in the outer layer of the egg) fromthe (enucleated) egg used in the nuclear replacement process.The implications of this for the compatibility of tissues derivedfrom embryos created by cell nuclear replacement (cloning) isnot known."²

For this reason, stem cells created by therapeutic cloning cannot be genetically identical because the embryonic stem cellswill contain the mitochondrial genes in the cytoplasm of the enucleatedfemale egg. Cloning causes serious biochemical and structuralproblems in animals.³ Mitochondrial damage would explain the. . . [Full text of this article]

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