BMJ 2001;323:632 ( 15 September )

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HIV-1 drug resistance in primary infections in the UK

The first 150 words of the full text of this article appear below.

EDITOR---The UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance reports an estimated prevalence of transmitted HIV drug resistance in 2000 of 27%.1

In an ongoing study of acute primary HIV infection at St Mary's Hospital, London, England, we have identified 28 seroconverters since January 2000. All patients sequenced to date (15/28) have no evidence of drug resistant mutations in either reverse transcriptase or protease before starting antiretroviral treatment. This is substantiated by the clinical response to treatment, with all subjects achieving an undetectable viral load before starting antiretroviral treatment.

The disparity in our findings is interesting, as the two cohorts are comparable. Our cohort was predominantly infected with clade B viruses (13/15). The median age was 30.5 years. All infections were transmitted sexually, except in one intravenous drug user. A possible explanation for the disparity is that seven of our patients were infected abroad, where antiretroviral treatment is less . . . [Full text of this article]
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Relevant Article

Analysis of prevalence of HIV-1 drug resistance in primary infections in the United Kingdom
UK Collaborative Group on Monitoring the Transmission of HIV Drug Resistance
BMJ 2001 322: 1087-1088. [Abstract] [Full Text] [PDF]

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