C reactive protein and acute phase of ischaemic stroke

doi:10.1136/bmj.322.7302.1605/a

BMJ 2001;322:1605 ( 30 June )

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C reactive protein and acute phase of ischaemic stroke

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EDITOR $---$ Higher C reactive protein concentrations indicate increased risk of coronary and cerebrovascular events in otherwisehealthy individuals¹ and a worse prognosis in myocardial infarction²and ischaemic stroke.³ According to Pepys and Berger, the availabledata support its potential role as a marker of cardiovascularrisk.⁴ To be of clinical use, however, the protein must havean independent prognostic value over and above that of the dataalready routinelyavailable.

In patients with acute myocardial infarction or ischaemic stroke the extent of necrosis is the main but not the only determinantof prognosis. Age and vascular comorbidity are not necessarilyrelated to infarct size but are nevertheless important predictorsof prognosis. The reasons for a variable response to the necroticinsult are probably multiple and require a clear understandingas they may represent independent additional determinants ofprognosis.

I looked again at data that colleagues and I obtained in . . . [Full text of this article]

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