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EDITOR
Higher C reactive protein concentrations indicate increased risk
of coronary and cerebrovascular events in otherwise healthy
individuals1 and a worse prognosis in myocardial
infarction2 and ischaemic stroke.3 According
to Pepys and Berger, the available data support its potential role as a
marker of cardiovascular risk.4 To be of clinical use,
however, the protein must have an independent prognostic value over and
above that of the data already routinely available.
In patients with acute myocardial infarction or ischaemic stroke the extent of necrosis is the main but not the only determinant of prognosis. Age and vascular comorbidity are not necessarily related to infarct size but are nevertheless important predictors of prognosis. The reasons for a variable response to the necrotic insult are probably multiple and require a clear understanding as they may represent independent additional determinants of prognosis.
I looked again at data that colleagues and I obtained in
Israeli students are refusing to perform intimate examinations on anaesthetised women without their informed consent.