Genetic contribution to osteoarthritis of the hip

doi:10.1136/bmj.322.7296.1247

BMJ 2001;322:1247 ( 19 May )

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Genetic contribution to osteoarthritis of the hip

Did ethics committee consult specialists?

Genetic contribution needs further investigation

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Did ethics committee consult specialists?

The first 150 words of the full text of this article appear below.

EDITOR $---$ Lanyon et al studied genetic factors associated with osteoarthritis of the hip, but how ethical is it to subject morethan 600 healthy participants (siblings of their original cohort)to pelvic radiography?¹ The authors used radiographs only asa diagnostic tool. Clinical examination using the Harris hip scorewould have more accurately obtained the diagnosis with the additionof information concerning loss of function and disease severity.Examination of the patient would have detected and excluded patientswith rheumatoidarthritis.

Despite the use of radiographs in this study, no information about the morphology of the hip joints was given. It would havebeen fascinating to measure the degree of femoral head cover,angle of acetabular inclination, and femoral shaft offset, whichgovern the magnitude and direction of forces, and the degree ofpressure concentration in the joint. Such morphological differencesexist between races and are believed to account for . . . [Full text of this article]

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Assessment of a genetic contribution to osteoarthritis of the hip: sibling study: Peter Lanyon, Kenneth Muir, Sally Doherty, and Michael Doherty
BMJ 2000 321: 1179-1183. [Abstract] [Full Text] [PDF]

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