BMJ 2001;322:1074-1075 ( 5 May )

Editorials

Is transmitted drug resistance in HIV on the rise?

It seems so

Papers p 1087

The first 150 words of the full text of this article appear below.

The transmission of drug resistant variants of HIV-1 has the potential seriously to limit the therapeutic options of newly infected patients. The selection of HIV drug resistant variants among individuals who are already receiving treatment also clearly limits both the size and duration of the viral supression induced by drug treatment. 1 2 Reports from North America and Europe indicate that up to 14% of recently infected patients have been infected with a strain of virus bearing well characterised drug resistance mutations (in 1-10% of cases) or reduced susceptibility to a particular drug (2-14% of cases).3-5 Temporal trends in the transmission of drug resistance for these populations are not yet available, but a paper from the United Kingdom in this week's BMJ suggests an increase in the risk of being infected with drug resistant HIV virus between 1994 and 2000 (p 1087).6

Estimates of the likelihood of transmission vary depending on the type . . . [Full text of this article]
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need for vaccine development
Ajit
bmj.com, 16 May 2001 [Full text]
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