BMJ 2001;322:1056-1059 ( 28 April )

Education and debate

Genetic risk and behavioural change

Theresa M Marteau, professor of health psychology ^a, Caryn Lerman, professor of oncology and psychiatry ^b. 

^a Psychology and Genetics Research Group, GKT Medical School, King's College London, Thomas Guy House, London SE1 9RT, ^b Cancer Control and Population Science, Georgetown University Medical Center, 2233 Wisconsin Avenue, Washington, DC 20007-4101, USA

Correspondence to: T M Marteau theresa.marteau@kcl.ac.uk

The first 150 words of the full text of this article appear below.

Predictive genetic testing is currently used mainly for untreatable conditions, such as Huntington's disease, or prenatal detection of serious genetic disorders such as cystic fibrosis. Prenatal tests are usually accompanied by an offer of termination of affected pregnancies. Genes have now been isolated that are associated with potentially preventable diseases such as heart disease and cancer and with increased risk from smoking and obesity. This has raised the possibility of providing predictive information to many more people. Such information may eventually reduce disease by facilitating the development of better targeted and more effective treatment.

Informing people of their genetic susceptibility to disease may motivate them to change their behaviour to reduce their risks. However, changing behaviour is often difficult. In this article we review the limited evidence concerning behavioural responses to genetic information on risk. We use this and the literature on behavioural change to consider if and how behaviour . . . [Full text of this article]

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