Human papillomavirus testing and the management of women with mildly abnormal cervical smears: an observational study

doi:10.1136/bmj.322.7291.893

BMJ 2001;322:893-894 ( 14 April )

Papers

Human papillomavirus testing and the management of women with mildly abnormal cervical smears: an observational study

Editorial by Manos

Gemma Rebello, consultant cytopathologist ^a, Nick Hallam, consultant virologist ^b, George Smart, consultant gynaecologist ^a, David Farquharson, patient services director, reproductive medicine ^a, Jane McCafferty, colposcopy sister ^a.

^a Colposcopy Clinic, Royal Infirmary of Edinburgh, Lothian University Hospitals NHS Trust, Edinburgh EH3 9YW, ^b Regional Clinical Virology Laboratory, City Hospital, Lothian University Hospitals NHS Trust, Edinburgh EH10 5SB

Correspondence to: N Hallam

The first 150 words of the full text of this article appear below.

Following publication of a report in Health Technology Assessment the NHS is running a pilot scheme screening women for humanpapillomavirus if they have a mildly dyskaryotic or borderlinesmear.¹How reliable is testing for human papillomavirus as a marker forhigh grade disease in those with mildly abnormalsmears?

Participants, methods, and results

Three hundred and thirty three consecutive new patients (aged 17 to 61 years, median 30 years) referred for colposcopy withpersistent borderline or mildly dyskaryotic smears and who consentedto the study were tested for human papillomavirus (high risk typesonly) with the Digene Hybrid Capture assay HC II (Abbott Laboratories,Maidenhead), by using cervical brush specimens placed in Digenetransport medium, and were treated by large loop excision of thetransformationzone.

The table summarises test performance, and table A on the BMJ 's website presents results by age, smear history, and testcut off.² Subjects aged under 30 years (166) were more . . . [Full text of this article]

CiteULike

Complore

Connotea

Del.icio.us Add to Digg

Digg

StumbleUpon Add to Technorati

Technorati What's this?

Relevant Articles

Human papillomavirus testing: Gemma Rebello, Nick Hallam, George Smart, David Farquharson, Jane McCafferty, and Julian Little
BMJ 2001 323: 109. [Extract] [Full Text]

Human papillomavirus is not an accurate marker for high grade disease
BMJ 2001 322: 0. [Full Text]

HPV testing for clarifying borderline cervical smear results: M Michele Manos
BMJ 2001 322: 878-879. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

Arbyn, M., Buntinx, F., Ranst, M. V., Paraskevaidis, E., Martin-Hirsch, P., Dillner, J. (2004). Virologic Versus Cytologic Triage of Women With Equivocal Pap Smears: A Meta-analysis of the Accuracy To Detect High-Grade Intraepithelial Neoplasia. JNCI J Natl Cancer Inst 96: 280-293 [Abstract] [Full text]
Philips, Z., Johnson, S., Avis, M., Whynes, D. K. (2003). Human papillomavirus and the value of screening: young women's knowledge of cervical cancer. Health Educ Res 18: 318-328 [Abstract] [Full text]
(2001). HPV Testing for Women with Borderline Abnormal Pap Smears. JWatch Women's Health 2001: 13-13 [Full text]
(2001). HPV Testing and the Diagnosis of Cervical Neoplasia. JWatch Infect. Diseases 2001: 5-5 [Full text]
Manos, M M. (2001). HPV testing for clarifying borderline cervical smear results. BMJ 322: 878-879 [Full text]

Rapid Responses:

Read all Rapid Responses

Human papillomavirus testing: Nick Hallam
bmj.com, 1 May 2001 [Full text]
HPV testing in triage of women with low-grade abnormal smears: Tombola Group
bmj.com, 4 May 2001 [Full text]