Treating non-ulcer dyspepsia and H pylori

doi:10.1136/bmj.321.7262.648

BMJ 2000;321:648-649 ( 16 September )

Editorials

Treating non-ulcer dyspepsia and H pylori

It is economically and clinically sensible but it won't make most patients better

Papers p 659

The first 150 words of the full text of this article appear below.

H elicobacter pylori is the main cause of duodenal and gastric ulcers. The organism has also been linked to gastric cancer.¹Most researchers believe that there is a relation, although animperfect one, between non-ulcer dyspepsia and infection withH pylori. The pathophysiological mechanisms by which the infectionmay cause dyspepsia are unclear, but may include changes in acidsecretion, abnormal motility, or altered visceral perception.²The prevalence of H pylori is higher in patients with non-ulcerdyspepsia than in healthy controls.³ A pivotal question iswhether curing the infection leads to a sustained improvementin symptoms in patients with non-ulcer dyspepsia. The controversysurrounding this issue is addressed by the meta-analysis by Moayyediet al in this issue of the journal (p 659).⁴

Dyspepsia is defined as pain or discomfort in the central upper abdomen which originates in the upper gastrointestinal tract.⁵To make the diagnosis of . . . [Full text of this article]

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Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia: Paul Moayyedi, Shelly Soo, Jonathan Deeks, David Forman, James Mason, Michael Innes, and Brendan Delaney
BMJ 2000 321: 659-664. [Abstract] [Full Text] [PDF]

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