BMJ 2000;321:187-188 ( 22 July )

Editorials

Heart disease and the inflammatory response

Although it's an integral part of the atherosclerotic process we still don't know why

Papers pp 199, 204, 208

The first 150 words of the full text of this article appear below.

Inflammation in the vessel wall plays an essential part not only in the initiation and progression of atherosclerosis but also in the erosion or fissure of plaques and, eventually, in the rupture of plaques.¹ Moreover, recent investigations have shown that various markers of systemic inflammation can predict future cardiovascular events including non-fatal and fatal myocardial infarction, stroke, and the progression of peripheral arterial occlusive disease in men and women regardless of whether they are known to have atherosclerosis. Most of the data available are on the role of fibrinogen, an acute phase protein, in coronary heart disease.² Other acute phase reactants, including leucocyte count, have also been consistently linked to the future risk of cardiovascular events.³

C reactive protein, the classic acute phase protein, was first associated with cardiovascular events in patients with coronary heart disease after analysis of prospective data from the European concerted action on thrombosis (ECAT) angina . . . [Full text of this article]

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