BMJ 2000;321:64-65 ( 8 July )

Editorials

Intranasal midazolam for febrile seizures

A step forward in treating a common and distressing condition

Papers p 83

The first 150 words of the full text of this article appear below.

Despite their benign nature and prognosis, uncomplicated febrile seizures are extremely stressful for both families and medical staff. Most parents believe that these seizures are harmful, and during the first episode half of all parents fear that their child is dying.1 For decades children were given long term anticonvulsant drugs to prevent the recurrence of febrile seizures. Although some of these are effective, their serious adverse effects have led to an unacceptable ratio of benefits to risks. 2 3

There is, however, a broad consensus that febrile seizures should be treated promptly. Traditionally, benzodiazepines, barbiturates, or other anticonvulsants have been given intravenously, but rectally administered diazepam is now used as an efficacious alternative.

The intranasal administration of therapeutic agents is undoubtedly the centre of tremendous interest in the field of therapeutics. That there is extensive and prompt absorption of molecules through the nasal mucosa into a rich vascular bed has long been . . . [Full text of this article]
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This article has been cited by other articles:

  • , , , R., , F. M, , B., , , , , , , , , , , , , , W., , (2001). Intranasal midazolam for treating febrile seizures in. BMJ 322: 107-107 [Full text]  
  • (2000). Intranasal Midazolam for Febrile Seizures. JWatch General 2000: 6-6 [Full text]  

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