BMJ 2000;320:1705-1706 ( 24 June )

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Infant mortality, stomach cancer, stroke, and coronary heart disease: ecological analysis

Editorial by Forman and Goodman

David A Leon, reader in epidemiology aGeorge Davey Smith, professor of clinical epidemiology b

a London School of Hygiene and Tropical Medicine, London WC1E 7HT, b Department of Social Medicine, University of Bristol, Bristol BS8 2PR

Correspondence to: D A Leon d.leon@lshtm.ac.uk

The first 150 words of the full text of this article appear below.

Mortality from stomach cancer and stroke shows an international correlation, consistent inverse socioeconomic gradients, a particular dependence on socioeconomic circumstances in childhood,1 and parallel patterns of decline in most industrialised countries over the past 30-40 years. The plausibility of the hypothesis that salt intake underlies this similarity has been weakened over the past decade as evidence for Helicobacter pylori as the key factor in the aetiology of non-cardia stomach cancer has increased.2 H pylori is thought to be acquired in childhood, and risk of infection is closely related to living conditions, hygiene, and housing standards. Geographical, socioeconomic, and secular variations in the prevalence of H pylori fit well with the corresponding trends and differences in mortality from stomach cancer between and within countries.2

Infant mortality in the early part of the 20th century indicates living conditions and, in particular, standards of hygiene. We investigated how far international variations in infant mortality . . . [Full text of this article]


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