ABC of arterial and venous disease: Vascular complications of diabetes

doi:10.1136/bmj.320.7241.1062

BMJ 2000;320:1062-1066 ( 15 April )

Clinical review

ABC of arterial and venous disease

Vascular complications of diabetes

Richard Donnelly, Alistair M Emslie-Smith, Iain D Gardner, Andrew D Morris.

The first 150 words of the full text of this article appear below.

Adults with diabetes have an annual mortality of about 5.4% (double the rate for non-diabetic adults), and their life expectancyis decreased on average by 5-10 years. Although the increaseddeath rate is mainly due to cardiovascular disease, deaths fromnon-cardiovascular causes are also increased. A diagnosis of diabetesimmediately increases the risk of developing various clinicalcomplications that are largely irreversible and due to microvascularor macrovascular disease. Duration of diabetes is an importantfactor in the pathogenesis of complications, but other risk factors $---$ forexample, hypertension, cigarette smoking, and hypercholesterolaemia $---$ interactwith diabetes to affect the clinical course of microangiopathyand macroangiopathy.

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Table Removed (Available Only in the Full Text)

Microvascular complications

A continuous relation exists between glycaemic control and the incidence and progression of microvascular complications. Hypertensionand smoking also have an adverse effect on microvascular outcomes.In the diabetes control and complications trial $---$ a landmark studyin type 1 diabetes $---$ the number of clinically important microvascularendpoints was . . . [Full text of this article]

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