Association between type 1 diabetes and Hib vaccine

BMJ 1999;319:1133 ( 23 October )

Letters

Association between type 1 diabetes and Hib vaccine

Causal relation is likely

More research is still needed

Causal relation is likely

The first 150 words of the full text of this article appear below.

EDITOR $---$ We initiated and funded a collaborative study with Tuomilehto on the effect of the Haemophilus influenzae type b vaccineon type 1 diabetes and found that the data support a causal relation(paper submitted for publication). Furthermore, the potentialrisk of the vaccine exceeds the potential benefit. We compareda group that received four doses of the vaccine, a group thatreceived one dose, and a group that was not vaccinated. The cumulativeincidence of diabetes per 100 000 in the three groups receivingfour, one, and no doses of the vaccine was 261, 237, and 207 atage 7 and 398, 376, and 340 at age 10respectively.

Karvonen et al's analysis is not rational, and their conclusion is not supported by our data.¹ Their calculations of relativerisk are also misleadingly low, and we urge readers to check them.Most researchers would compare the group who received four doseswith the group that was not . . . [Full text of this article]

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Relevant Article

Association between type 1 diabetes and Haemophilus influenzae type b vaccination: birth cohort study: Marjatta Karvonen, Zygimantas Cepaitis, and Jaakko Tuomilehto
BMJ 1999 318: 1169-1172. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

HEININGER, U. (2000). Coincidence is not causality---a principle which needs regular rediscovery. Arch. Dis. Child. 83: 355-355 [Full text]

Rapid Responses:

Read all Rapid Responses

Borderline significance of relative risk for association between type 1�diabetes and Hib vaccine: Hans Thulesius
bmj.com, 22 Oct 1999 [Full text]
Parents'' Response: Brenda Brandt
bmj.com, 1 Nov 1999 [Full text]
Not coincidence: Sandy Stanford
bmj.com, 2 Nov 1999 [Full text]
Keep Researching this please.: Stephanie Haven
bmj.com, 6 Nov 1999 [Full text]
Association between type 1 diabetes and Hib vaccine: J Claire Bramley
bmj.com, 12 Nov 1999 [Full text]
Re: Association between type 1 diabetes and Hib vaccine: John P Heptonstall
bmj.com, 23 Nov 1999 [Full text]
Diabetes and haemophilus influenzae vaccination: A Juche, et al.
bmj.com, 22 Nov 1999 [Full text]
Response: Jinny Willis
bmj.com, 6 Dec 1999 [Full text]
Re: Response: Bart Classen
bmj.com, 28 Jan 2000 [Full text]