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EDITOR
Given the evidence presented in the POST study, a well designed
cluster randomised trial, we were a little surprised that the
investigators concluded that postal prompts to general practitioners
have a "marginal role" in improving the secondary prevention of
coronary heart disease.1
The authors found that recording and advice were significantly
increased for all except one of the measures of risk factor, dramatically so for some measures (such as recorded cholesterol measurement). Also, for their principal prescribing outcome measures (
blockers and cholesterol lowering drugs), the odds ratio was non-significantly raised to 1.7
which, if real, seems clinically important. The failure to detect a statistically significant difference may reflect the absence of a real effect or simply a type 2 error due
to insufficient power.
We agree that the overall level of prescribing of
blockers and
cholesterol lowering drugs in both arms of the study was disappointing.
The finding that