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Obioha C Ukoumunne a Department of Public Health Sciences,
Guy's, King's, and St Thomas's School of Medicine, King's College,
London SE1 3QD, b Department of Epidemiology
and Biostatistics, University of Western Ontario, London, Ontario,
Canada N6A 5C1
Correspondence to: MC Gulliford
martin.gulliford@kcl.ac.uk
The first 150 words of the full text of this article appear below.
Healthcare interventions are often implemented at the level of the organisation or geographical area rather than at the level of the individual patient or healthy subject. For example, screening programmes are delivered to residents of a particular area; health promotion interventions might be delivered to towns or schools; general practitioners deliver services to general practice populations; hospital specialists deliver health care to clinic populations. Interventions at area or organisation level are delivered to clusters of individuals.
The evaluation of interventions based in an area or organisation may
require the allocation of clusters of individuals to different
intervention groups (see box 1).
1 2
Cluster based evaluations present special problems both in design and
analysis.3 Often only a small number of organisational
units of large size are available for study, and the investigator needs
to consider the most effective way of designing a study with this
constraint. Outcomes may be evaluated either