Prenatal and perinatal risk factors for psychiatric diseases of early onset

BMJ 1999;318:1622 ( 12 June )

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Prenatal and perinatal risk factors for psychiatric diseases of early onset

Results are different if seasons are categorised differently

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Results are different if seasons are categorised differently

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EDITOR $---$ Hultman et al found that late winter births are associated with increased risks of schizophrenia and affective psychosis,the odds ratios being 1.4 and 1.5 respectively.¹ The authorspresented the excess of late winter births as one of their keymessages, although the finding reached significance only amongmale subjects with affective psychosis.

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Using the northern Finland 1966 birth cohort (5636 male and 5381 female subjects), we partially replicated Hultman et al'sstudy. The cohort is a genetically homogeneous population, anddata are available on biological, socioeconomic, environmental,and health conditions for every individual from mid-pregnancyof their mother to the age of 31. Psychiatric diagnoses were madeon the basis of extracts from the Finnish national hospital dischargeregister and a detailed diagnostic validation process.² Birthseasonality was examined separately in those with schizophrenia(Diagnostic and Statistical Manual of Mental Disorders, thirdedition, revised, code 295; n=105) and those with no . . . [Full text of this article]

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Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactive psychosis of early onset: case-control study • Prenatal and perinatal risk factors for early onset schizophrenia, affective psychosis, and reactive psychosis: Christina M Hultman, Pär Sparén, Noriyoshi Takei, Robin M Murray, Sven Cnattingius, and John Geddes
BMJ 1999 318: 421-426. [Abstract] [Full Text] [PDF]

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