Albumin again

BMJ 1999;318:1352 ( 15 May )

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Albumin again

The first 150 words of the full text of this article appear below.

EDITOR $---$ There are only two explanations for the conclusions of the Cochrane review of human albumin administration in criticallyill patients $---$ either that albumin was given in excessive amountsor that the commercial processing it undergoes makes it toxic.Several correspondents writing about the review call for expertappraisal of the evidence on which it was based.¹

As a start I suggest that attention should be directed to the numerous papers published by the Detroit group, all based onthe same 52 patients; five of these studies are included in thereview. Lucas et al gave the 27 patients in the albumin group24% albumin during resuscitation followed by a dose of 150 g/dayfor five days postoperatively, this dose being "selected to restorealbumin levels to normal."² Simultaneously, whole blood, freshfrozen plasma, and Ringer-lactate solution were given in amountsgreater than to the control group, resulting in a weight gain. . . [Full text of this article]

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BMJ 1998 317: 882. [Extract] [Full Text] [PDF]