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Having several guidelines is confusing
| The first 150 words of the full text of this article appear below. |
EDITOR
Unwin et al highlight the fact that several widely available
guidelines for the management of hyperlipidaemia give conflicting
advice for the primary prevention of cardiovascular disease.1 Some of the issues deserve further scrutiny.
The New Zealand guidelines are based entirely on the ratio of total to
high density lipoprotein cholesterol concentrations for calculation of
the absolute risk of cardiovascular disease over five
years.2 The American national cholesterol education program, however, clearly says that it does not recommend use of the
ratio of either total or low density lipoprotein cholesterol to high
density lipoprotein cholesterol3; instead it recommends use of the absolute high and low density lipoprotein cholesterol concentrations. The rationale behind this is that these concentrations are independent risk factors with different determinants; combining them into a single number conceals information about either or both,
which might be important for making clinical decisions. A patient with
raised
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