BMJ 1999;318:593-596 ( 27 February )

Education and debate

Clinical guidelines

Developing guidelines

This is the second in a series of four articles on issues in the development and use of clinical guidelines

Paul G Shekelle, senior research associate, Health Services Research and Development Servicea Steven H Woolf, professor of family medicineb Martin Eccles, professor of clinical effectivenessc Jeremy Grimshaw, professor of public healthd

a West Los Angeles Veterans Affairs Medical Center (111G), 11301 Wilshire Blvd, Los Angeles, CA 90073, USA, b Department of Family Practice, Virginia Commonwealth University, Fairfax, Virginia 22033, USA, c Centre For Health Services Research, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4AA, d Health Services Research Unit, University of Aberdeen, Aberdeen AB9 2ZD

Correspondence to: Dr Shekelle shekelle@rand.org

The first 150 words of the full text of this article appear below.

The methods of guideline development should ensure that treating patients according to the guidelines will achieve the outcomes that are desired. This article presents a combination of the literature about guideline development and the results of our combined experience in guideline development in North America and Britain. It considers the five steps in the initial development of an evidence based guideline. The dissemination, implementation, and evaluation of practice guidelines will be discussed in the final article in this series.1


Table Removed (Available Only in the Full Text)


    Identifying and refining the subject area of a guideline

Prioritising topics
Guidelines can be developed for a wide range of subjects. Clinical areas can be concerned with conditions (abnormal uterine bleeding, coronary artery disease) or procedures (hysterectomy, coronary artery bypass surgery). Given the large number of potential areas, some priority setting is needed to select an area for guideline development. Potential areas can emerge from an assessment of the major causes of morbidity and mortality for a given population, uncertainty . . . [Full text of this article]


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  • Merlani, P., Garnerin, P., Diby, M., Ferring, M., Ricou, B. (2001). Quality Improvement Report: Linking guideline to regular feedback to increase appropriate requests for clinical tests: blood gas analysis in intensive care. BMJ 323: 620-624 [Abstract] [Full text]  
  • Pickering, T. (2001). Job Stress, Control, and Chronic Disease: Moving to the Next Level of Evidence. Psychosom. Med. 63: 734-736 [Full text]  
  • McQueen, M. J. (2001). Overview of Evidence-based Medicine: Challenges for Evidence-based Laboratory Medicine. Clin. Chem. 47: 1536-1546 [Abstract] [Full text]  
  • Shekelle, P., Eccles, M. P, Grimshaw, J. M, Woolf, S. H (2001). When should clinical guidelines be updated?. BMJ 323: 155-157 [Full text]  
  • YOUNG, A. H. (2001). Recurrent unipolar depression requires prolonged treatment. Br. J. Psychiatry 178: 294-295 [Full text]  
  • Smith, W. R. (2000). Evidence for the Effectiveness of Techniques To Change Physician Behavior. Chest 118 : 8S-17S [Abstract] [Full text]  
  • Eccles, M., Mason, J., Freemantle, N. (2000). Developing valid cost effectiveness guidelines: a methodological report from the North of England evidence based guideline development project. Qual Saf Health Care 9: 127-132 [Full text]  
  • O'Brien, E., Coats, A., Owens, P., Petrie, J., Padfield, P. L, Littler, W. A, de Swiet, M., Mee, F. (2000). Use and interpretation of ambulatory blood pressure monitoring: recommendations of the British Hypertension Society. BMJ 320: 1128-1134 [Full text]  
  • Khakoo, G A, Lack, G (2000). Recommendations for using MMR vaccine in children allergic to eggs. BMJ 320: 929-932 [Full text]  
  • Anderson, I. M., Nutt, D. J., Deakin, J. F. W. (2000). Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 1993 British Association for Psychopharmacology guidelines. J Psychopharmacol 14: 3-20 [Abstract]  
  • Feder, G., Eccles, M., Grol, R., Griffiths, C., Grimshaw, J. (1999). Clinical guidelines: Using clinical guidelines. BMJ 318: 728-730 [Full text]  



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