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EDITOR
Marshall and Spiegelhalter have done a valuable service in
questioning the reliability of the Human Fertilisation and Embryology
Authority's league tables of in vitro fertilisation clinics.1 Unfortunately, the tables are probably even less reliable than these authors suggest.
The authority reports adjusted life birth rates, which are based mostly
on the female patient's age. As the method of adjustment is
unpublished one cannot judge whether the various factors are weighted
correctly. Moreover, this adjustment does not embody all factors
affecting outcome. These include an accurate record of the number of
previous cycles of in vitro fertilisation, basal follicle stimulating
hormone concentrations, amount of gonadotrophin needed before eggs are
collected, total ovarian response, and number of embryos transferred.
Some clinics attempt to reduce the incidence of triplet pregnancy by
transferring only two embryos except where prognosis is known to be
poor. Others try to increase success, but also increase