Early diagnosis of cystic fibrosis can improve children's growth

BMJ 1998;317:1017 ( 10 October )

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Early diagnosis of cystic fibrosis can improve children's growth

The first 150 words of the full text of this article appear below.

EDITOR $---$ Wald and Morris¹ seem to have examined carefully our article on the nutritional benefits of neonatal screening incystic fibrosis² but they misunderstood some points and failedto grasp the potential advantages of preventing malnutrition inpatients with cysticfibrosis.

They comment that our "study design is an ingenious one, but the analysis of the results is problematic." Ironically, themost ingenious feature is the very element they criticise withtheir comment that "a difficulty that is not discussed ... isthat the data in children under 4 years are subject to selectionbias." Selection bias was one of the challenges we overcame inour study design. Our randomisation protocol was designed to includea group that had been screened at birth and a standard diagnosis(control)group.

Once the controls were identified by the unblinding process at 4 years of age, their anthropometric indices of nutritionalstatus since birth were . . . [Full text of this article]

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Neonatal screening for cystic fibrosis: Nicholas J Wald and Joan K Morris
BMJ 1998 316: 404-405. [Extract] [Full Text]

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