BMJ 1998;316:1255-1256 ( 25 April )

Editorials

Antibiotic resistance: an increasing problem?

It always has been, but there are things we can do

News p 1261.

The first 150 words of the full text of this article appear below.

Although the "antibiotic era" dates from Fleming's discovery of the effects of the fungus Penicillium notatum in 1928, not until 1940 could penicillin be produced in a sufficiently pure form to treat humans.¹ Ominously, a  lactamase (penicillinase) capable of inactivating penicillin was described in the previous year. Over the next few decades the production of new classes of antibiotics (derived from living organisms) and antimicrobials (synthesised chemicals) increased exponentially, and the burden of infection was lifted, especially in developed countries. In recent years concern has increased that the antibiotic era might be coming to an endfirstly, because the rate of production of new agents has diminished greatly and, secondly, because viruses, bacteria, fungi, protozoa, and parasites are showing great ingenuity in devising mechanisms for circumventing the killing activity of such agents.

So great is the concern that several committees both in the United Kingdom and elsewhere are examining different aspects of . . . [Full text of this article]

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