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Acute angle closure glaucoma associated with paroxetine

An 84 year old woman was taking frusemide, digoxin, lisinopril, and ranitidine to control longstanding hypertension, atrial fibrillation, angina, and oesophagitis. She developed symptoms of depression, and treatment with paroxetine (Seroxat) was started at a dose of 10 mg daily, increasing after 10 days to 20 mg/day. After three days of treatment with the higher dose her right eye became painful and red, with blurring of vision. Ocular examination showed hypermetropia, the left eye having a narrow drainage angle predisposed to angle closure. The right eye showed established angle closure, with corneal oedema and a raised intraocular pressure of 40 mm Hg. Paroxetine was withdrawn, and the eyes responded to a standard regimen of medical treatment followed by laser iridotomies.

In this case there was a clear temporal link between paroxetine administration and the development . . . [Full text of this article]

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