BMJ 1996;313:1554-1555 (14 December)

Letters

Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy

EDITOR,--Hans-Henrik Parving and colleagues report that patients with diabetic nephropathy who were homozygous for a deletion polymorphism of the angiotensin converting enzyme gene progressed more rapidly towards renal failure than did other diabetic patients with diabetic nephropathy once glycaemic control was controlled for in their analysis.1 This is consistent with the results of a study that we published two years ago2 but contrasts with a previous report from the same group.3

There are two possible reasons for the discrepancy between Parving and colleagues' initial3 and most recent1 findings. Firstly, the controls in their first study were not matched to the cases for glycaemic control3 (unlike in our study2), yet diabetic nephropathy occurs only in patients with inadequate glycaemic control. Secondly, a deletion polymorphism of the angiotensin converting enzyme gene may act on the progression of, but not susceptibility to, diabetic nephropathy. In Parving and colleagues' latest study subjects homozygous . . . [Full text of this article]


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Relevant Article

Effect of deletion polymorphism of angiotensin converting enzyme gene on progression of diabetic nephropathy during inhibition of angiotensin converting enzyme: observational follow up study
Hans-Henrik Parving, Peter Jacobsen, Lise Tarnow, Peter Rossing, Laure Lecerf, Odette Poirier, and Francois Cambien
BMJ 1996 313: 591-594. [Abstract] [Full Text]

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