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EDITOR,--Charlotte M Wright and colleagues report a discrepancy between the sexes in weight in infancy1 when the British 1990 growth reference2 was used to standardise the weights of infants in Newcastle upon Tyne. They suggest that this arises from a bias in the growth reference rather than a regional difference in growth.
We looked for a possible regional effect in a cohort of 7400 babies from West Sussex, who were measured between birth and 35 weeks (courtesy of Dr Ann Wallace). As in Newcastle, there was no sex difference in the standard deviation score for weight at birth, but thereafter the boys' weight centiles tended to exceed the girls' (by a mean score of 0.31, compared with 0.41 in the authors' study). Thus regional differences alone are unlikely to explain the finding, and a bias in the growth reference must exist. We
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