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The results of the west of Scotland coronary prevention study of pravastatin treatment in men with raised cholesterol concentration showed a headline reduction of 32% in cardiovascular mortality and 22% in all cause mortality after five years.2 The Scandinavian simvastatin survival study of simvastatin treatment in the secondary prevention of coronary heart disease addressed a related issue but in a group with a much higher risk of premature death.3
What are the costs and benefits of these interventions likely to be in practice?
In the case of primary prevention, a general practitioner's list of 2000 patients will contain about 75 men aged 45-65
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