BMJ 1996;312:1608 (22 June)

Letters

Metabolic effects of hormone replacement preparations

EDITOR,--The recent article by the Medical Research Council's General Practice Research Framework examined the metabolic effects of an oestrogen only and a combined hormone replacement preparation (containing norgesterol) in women with hysterectomy and concluded that the possibly beneficial and adverse effects of the two regimens were fairly evenly balanced on lipids and coagulability.1 We believe that a greater emphasis should have been placed on the results for high density lipoprotein cholesterol, which is a potent independent risk factor for coronary heart disease in women of that age. In the lipid research clinics prevalence study, high density lipoprotein cholesterol was second only to age as a predictor of coronary heart disease in women, more so than low density lipoprotein cholesterol.2 From the Framingham data3 we calculated that for a similar group of women the difference in high density lipoprotein cholesterol concentration observed at 12 months between oestrogen only and the combined . . . [Full text of this article]


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Relevant Article

Randomised comparison of oestrogen versus oestrogen plus progestogen hormone replacement therapy in women with hysterectomy
BMJ 1996 312: 473-478. [Abstract] [Full Text]

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