BMJ 1996;312:521-522 (2 March)

Editorials

Managing HIV disease after Delta

Questions remain about how to manage patients already on nucleoside monotherapy

It is not often that the results of clinical trials change clinical practice almost overnight. But that is what has happened with two clinical trials (Delta and ACTG175) of combination nucleoside analogue antiretroviral treatment for patients infected with HIV. The previously standard monotherapy had evident limitations in the extent and durability of response. The need for and expectations of better treatments was high, fuelling but also distorting the investigation of improved approaches. What are the practical implications of these studies?

Delta (conducted by a European/Australian group coordinated by Britain's Medical Research Council and the Agence National de Recherches sur le SIDA in France) and ACTG175 (conducted in the United States by the AIDS Clinical Trials Group of the National Institutes of Health) have recently released their main findings. They were large randomised double blind placebo controlled trials of zidovudine . . . [Full text of this article]


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to StumbleUpon StumbleUpon   Add to Technorati Technorati    What's this?

Relevant Article

Managing HIV disease without Delta
R A Seaton, A J France, and D Nathwani
BMJ 1996 312: 1542. [Extract] [Full Text]

This article has been cited by other articles:

  • Mok, J., Cooper, S. (1997). The needs of children whose mothers have HIV infection. Arch. Dis. Child. 77: 483-487 [Abstract] [Full text]  
  • SHARLAND, M., GIBB, D., TUDOR-WILLIAMS, G., WALTERS, S., NOVELLI, V. (1997). Paediatric HIV infection. Arch. Dis. Child. 76: 293-296 [Full text]  
  • Phillips, A. N, Smith, G. D., Johnson, M. A (1996). For Debate: Will we ever know when to treat HIV infection?. BMJ 313: 608-610 [Full text]  
  • Seaton, R A, France, A J, Nathwani, D (1996). Managing HIV disease without Delta. BMJ 312: 1542b-1542 [Full text]  
Access jobs at BMJ Careers
Whats new online at Student BMJ