BMJ 1996;312:311 (3 February)

Letters

Fc(epsilon)RI-(beta) polymorphisms unlikely to contribute substantially to genetic risk of allergic disease

EDITOR,--M R Hill and colleagues report the association between a variant of the gene for the ß chain of the high affinity receptor for IgE (Fc(epsilon)RI-ß) with the Leu 181/Leu 183 polymorphism and atopy in an Australian population.1 They suggest that polymorphism in Fc(epsilon)RI-ß is one factor that can be used to assign genetic risk of atopy. This group has previously suggested that Leu 181 may be associated with atopy in the British population.2

As part of a study examining the relation between ß2 adrenoceptor polymorphisms and airway reactivity3 we recently screened a population of asthmatic patients for Fc(epsilon)RI-ß polymorphisms. Polymerase chain reaction based on the amplification refractory mutation system failed to identify any subjects with either the Leu 181 or the Leu 181/Leu 183 polymorphism. We therefore proceeded to direct sequencing of this region of Fc(epsilon)RI-ß to ensure that our ability to detect the Leu 181 polymorphism was . . . [Full text of this article]


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Relevant Article

Fc(epsilon)RI-(beta) polymorphism and risk of atopy in a general population sample
M R Hill, A L James, J A Faux, G Ryan, J M Hopkin, P le Souef, A W Musk, and W O C M Cookson
BMJ 1995 311: 776-779. [Abstract] [Full Text]

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