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EDITOR,--To answer the questions of Sarah Vause and colleagues in reverse order, I can reassure them that the data given in our paper referred only to singleton pregnancies. This information was included in our original submission but was inadvertently omitted when we revised the paper to answer points made by referees. I am grateful for the chance to put the record straight.The St Mary's maternity information system records the lowest haemoglobin concentration but not the gestation at which the lowest value occurred. The references we quoted in our paper make it clear that most of the expansion in plasma volume (which is reflected in the fall in haemoglobin concentration) has occurred by 20-24 weeks' gestation and there is comparatively little change thereafter. Thus, estimation of haemoglobin concentration at any gestation after 24 weeks is likely to show a similar relation with birth weight.
Finally, although we referred mainly to
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