BMJ 1995;310:1005-1006 (15 April)

Letters

United Kingdom prospective diabetes study

Compliance with diet will affect results

EDITOR,--As a result of its comparison of the relative efficacy of diet and various drug treatments in patients with newly diagnosed diabetes the United Kingdom Prospective Diabetes Study Group concludes that chlorpropamide, glibenclamide, insulin, and metformin are more effective than diet alone.1 The group does not present any evidence on what diets the subjects were given, what baseline diets were being consumed, whether diets changed during the study, or whether the subjects complied with the given dietary regimen. The authors did not consider whether there was any change in the dietary prescriptions over the 10 years of the study which might also have influenced the results. From figure 2 it is apparent that body weight did not change in any group, which suggests that, at least in obese subjects, those taking diet alone did not achieve the dietary objective of a reduction in weight. . . . [Full text of this article]


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Relevant Article

United Kingdom prospective diabetes study (UKPDS) 13: relative efficacy of randomly allocated diet, sulphonylurea, insulin, or metformin in patients with newly diagnosed non-insulin dependent diabetes followed for three years
BMJ 1995 310: 83-88. [Abstract] [Full Text]

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