Letters
Thalidomide may not be a mutagen
EDITOR, - I wish to comment on W G McBride's report of two children with malformations whose fathers are thalidomide victims.1 In case 1 the father is described as having no thumb on the right hand while the child has no thumb and only two digits on both hands. As far as I can tell from the photographs, however, the child's malformations seem to be the result of split hands, while the father's malformations seem to be something other than a radial ray defect. I believe that both the father and the child have split hand deformity (McKusick definition), which is autosomal dominant. Alternatively, the father's malformations could be part of a construction band syndrome (an amniotic band, with amputation of the thumb), which is thought to be sporadic. In case 2 the photographs show radial ray defects (thalidomide embryopathy in particular) in both the father and daughter. These may
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BMJ 1994 308: 1635.[Extract] [Full Text]
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