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Bone marrow transplants from peripheral blood
EDITOR, - Reinfusion of peripheral blood stem cells to repopulate the bone marrow after myeloablative chemotherapy is being increasingly used to intensify treatment for haematological and other malignancies.1 We could find no published data on the practicalities of returning the cells to the patient through a central venous line. One method is to inject the stem cell suspension with a yringe, but problems may occur in maintaining sterility; in addition, too rapid injection may result in an adverse reaction to the cryopreservative (dimethyl sulphoxide) in which the cells are suspended.
An alternative method is reinfusion with a standard blood giving set, but, using this technique, we have observed accumulation of cellular sediment within and around the 170 µ m filters of such sets. Since the cell suspension harvested with a Haemonetics V50 cell separator contains platelets of the order of 1012/l these were probably contributing to the cellular sediment
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- Bone marrow transplants from peripheral blood
- T L Holyoake and I M Franklin
BMJ 1994 309: 4-5.[Extract] [Full Text]
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