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Side effects are estimated to occur at a frequency of between 1 in 1000 to 1 in 10 000 treatments involving restorative materials.1 Most reactions are mild, but severe allergic reactions occur rarely. The typical allergic response to dental materials is a delayed contact hypersensitivity reaction (type IV), which can be initiated by minute amounts of the allergen in sensitised individuals. Toxic reactions, on the other hand, are dose dependent. Minute amounts
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