BMJ 1994;309:283-284 (30 July)

Editorials

Long term survival in HIV-1 infection

Several recent cohort studies have documented that a proportion of people who have been infected with HIV-1 for 10 years or more remain not only free of AIDS but also free of symptoms.*RF 1-6* Studies of homosexual and bisexual men have found that about half remain free of AIDS 10 years after initially becoming infected,*RF 1-3,5* and one of these studies, the San Francisco City Clinic cohort study, has found that 8% of men infected for between 10 and 15 years remain clinically normal, with only minor immunological and haematological abnormalities.1 Similarly, studies of people infected parenterally through either blood transfusions or anti-haemophilic factors have shown that a substantial proportion remain free of AIDS, even in the oldest age groups, after prolonged HIV-1 infection.4,6

Epidemiologists are now modelling these cohort studies to look further into the future for these patients. In this week's journal Phillips and colleagues from the Royal . . . [Full text of this article]


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