BMJ 1994;308:1716-1717 (25 June)

Letters

Cancer of the upper gastrointestinal tract

EDITOR, - In their letter J G Weil and S J Munday provide further evidence of surgeons' experience as a prognostic factor and in their subsequent editorial S O'Reilly and A Forastiere draw attention to the potential value of multimodality in the management of oesophageal cancer. We wish to emphasise the worldwide paucity of randomised trials in this disease; this could well be delaying improvements in treatment. To help rectify this situation, in 1990 the Medical Research Council's Cancer Therapy Committee set up a working party to conduct a programme of multicentre randomised trials on treatment. This programme is progressing well.

Firstly, 204 of a planned intake of 1000 patients have to date been entered into an international trial of simple design, started in 1992, comparing surgical resection with or without two cycles of preoperative chemotherapy (OE02 trial). This complements the similar intergroup trial in the United States mentioned by . . . [Full text of this article]


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Relevant Article

Management of oesophageal cancer
J G Weil and S J Munday
BMJ 1994 308: 1103. [Extract] [Full Text]

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