BMJ 1994;308:1710 (25 June)
Letters
Hepatitis C virus infection
EDITOR, - Carol A Seymour's editorial1 and the papers on hepatitis C in the same issue illustrate the problems of defining chronic hepatitis C and of identifying patients who would benefit from regular follow up in a gastroenterology clinic. We and colleagues have found that only liver biopsy reliably identifies patients with chronic infection. Kate E Ryan and colleagues rightly question the effectiveness of counselling when so little is known of the natural course of this infection.2
Liver biopsy is not a minor procedure, and scarce and expensive medical resources should be used only when the patient will benefit. The patient must be given an accurate prognosis and treatment with interferon alfa and other antivirals should be offered when appropriate, although the long term effects of such intervention on the prognosis of liver disease associated with hepatitis C are unknown.
Much of this information is not new. It has been . . . [Full text of this article]

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Asymptomatic infection with hepatitis C virus
- C A Seymour
BMJ 1994 308: 670-671.
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