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The power calculation is based on 569 subjects, but data is provided for only 485 (239 monitoring peak expiratory flow, 246 controls); what about the other 84 patients? The physicians' guidelines included two action levels depending on peak expiratory flow: when to start oral steroids (for severe episodes of asthma) and when to seek medical assistance. Given that patients with mild asthma were selected (those possessing peak flow meters were excluded from randomisation) and the weak power, the study design biased evaluation against effective routine self monitoring of peak expiratory flow.
At least four hospital centres (and an unstated number of
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