Papers

Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women

Institut National de la Sante et de la Recherche Medicale U 234. Service de Rhumatologie et de la Pathologie Osseuse, Pavillon F, Hopital Edouard Herriot, 69437 Lyons Cedex 3, France.

We recently showed that daily supplementation with 1.2 g calcium and 800 IU cholecalciferol over 18 months substantially decreased the risk of hip fractures and other non-vertebral fractures in elderly women living in nursing homes.¹ We report the results of a further 18 months of treatment.

Subjects, methods, and results

A total of 3270 mobile elderly women (mean age 84 (SD 6) years) living in 180 nursing homes were enrolled in the study. Half the women received 1.2 g calcium daily in the form of tricalcium phosphate, together with 800 IU (20 µg) cholecalciferol; the other half received a double placebo. All subjects were followed up every six months; biochemical variables were measured at baseline and every year in a subgroup of 52 women. Hip fractures and all non-vertebral fractures were separately analysed using a log rank test and an actuarial method; 95% confidence intervals are . . . [Full text of this article]

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    StumbleUpon    Technorati    What's this?

Relevant Articles

Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial

Mark J Bolland, P Alan Barber, Robert N Doughty, Barbara Mason, Anne Horne, Ruth Ames, Gregory D Gamble, Andrew Grey, and Ian R Reid
BMJ 2008 336: 262-266. [Abstract] [Full Text] [PDF]

Hip fracture

Martyn Parker and Antony Johansen
BMJ 2006 333: 27-30. [Extract] [Full Text] [PDF]

Calcium, vitamin D, and hip fractures Incidence of falls may have decreased

T Mets, D Torgerson, and M Campbell
BMJ 1994 309: 193. [Extract] [Full Text]

This article has been cited by other articles:

• Bischoff-Ferrari, H. A., Willett, W. C., Wong, J. B., Stuck, A. E., Staehelin, H. B., Orav, E. J., Thoma, A., Kiel, D. P., Henschkowski, J. (2009). Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency: A Meta-analysis of Randomized Controlled Trials. Arch Intern Med 169: 551-561 [Abstract] [Full text]  
• Hegge, K. A., Fornoff, A. S., Gutierres, S. L., Haack, S. L. (2009). New Therapies for Osteoporosis. Journal of Pharmacy Practice 22: 53-64 [Abstract]  
• Heaney, R. P. (2009). Dairy and Bone Health. J. Am. Coll. Nutr. 28: 82S-90S [Abstract] [Full text]  
• Cole, Z., Dennison, E., Cooper, C. (2008). Update on the treatment of post-menopausal osteoporosis. Br Med Bull 86: 129-143 [Abstract] [Full text]  
• Bolland, M. J, Barber, P A., Doughty, R. N, Mason, B., Horne, A., Ames, R., Gamble, G. D, Grey, A., Reid, I. R (2008). Vascular events in healthy older women receiving calcium supplementation: randomised controlled trial. BMJ 336: 262-266 [Abstract] [Full text]  
• Boonen, S., Lips, P., Bouillon, R., Bischoff-Ferrari, H. A., Vanderschueren, D., Haentjens, P. (2007). Need for Additional Calcium to Reduce the Risk of Hip Fracture with Vitamin D Supplementation: Evidence from a Comparative Metaanalysis of Randomized Controlled Trials. J. Clin. Endocrinol. Metab. 92: 1415-1423 [Abstract] [Full text]  
• Jackson, C., Gaugris, S., Sen, S.S., Hosking, D. (2007). The effect of cholecalciferol (vitamin D3) on the risk of fall and fracture: a meta-analysis. QJM 100: 185-192 [Abstract] [Full text]  
• Lentle, B., Worsley, D. (2006). Osteoporosis Redux. JNM 47: 1945-1959 [Full text]  
• Law, M., Withers, H., Morris, J., Anderson, F. (2006). Vitamin D supplementation and the prevention of fractures and falls: results of a randomised trial in elderly people in residential accommodation. Age Ageing 35: 482-486 [Abstract] [Full text]  
• Parker, M., Johansen, A. (2006). Hip fracture.. BMJ 333: 27-30 [Full text]  
• Cockayne, S., Adamson, J., Lanham-New, S., Shearer, M. J., Gilbody, S., Torgerson, D. J. (2006). Vitamin K and the Prevention of Fractures: Systematic Review and Meta-analysis of Randomized Controlled Trials.. Arch Intern Med 166: 1256-1261 [Abstract] [Full text]  
• Francis, R.M., Anderson, F.H., Patel, S., Sahota, O., van Staa, T.P. (2006). Calcium and vitamin D in the prevention of osteoporotic fractures. QJM 99: 355-363 [Full text]  
• Jackson, R. D., LaCroix, A. Z., Gass, M., Wallace, R. B., Robbins, J., Lewis, C. E., Bassford, T., Beresford, S. A.A., Black, H. R., Blanchette, P., Bonds, D. E., Brunner, R. L., Brzyski, R. G., Caan, B., Cauley, J. A., Chlebowski, R. T., Cummings, S. R., Granek, I., Hays, J., Heiss, G., Hendrix, S. L., Howard, B. V., Hsia, J., Hubbell, F. A., Johnson, K. C., Judd, H., Kotchen, J. M., Kuller, L. H., Langer, R. D., Lasser, N. L., Limacher, M. C., Ludlam, S., Manson, J. E., Margolis, K. L., McGowan, J., Ockene, J. K., O'Sullivan, M. J., Phillips, L., Prentice, R. L., Sarto, G. E., Stefanick, M. L., Van Horn, L., Wactawski-Wende, J., Whitlock, E., Anderson, G. L., Assaf, A. R., Barad, D., the Women's Health Initiative Investigators, (2006). Calcium plus Vitamin D Supplementation and the Risk of Fractures. NEJM 354: 669-683 [Abstract] [Full text]  
• Karlsson, M. K., Gerdhem, P., Ahlborg, H. G. (2005). The prevention of osteoporotic fractures. J Bone Joint Surg Br 87-B: 1320-1327 [Full text]  
• Hodsman, A. B., Bauer, D. C., Dempster, D. W., Dian, L., Hanley, D. A., Harris, S. T., Kendler, D. L., McClung, M. R., Miller, P. D., Olszynski, W. P., Orwoll, E., Yuen, C. K. (2005). Parathyroid Hormone and Teriparatide for the Treatment of Osteoporosis: A Review of the Evidence and Suggested Guidelines for Its Use. Endocr. Rev. 26: 688-703 [Abstract] [Full text]  
• Bischoff-Ferrari, H. A., Willett, W. C., Wong, J. B., Giovannucci, E., Dietrich, T., Dawson-Hughes, B. (2005). Fracture Prevention With Vitamin D Supplementation: A Meta-analysis of Randomized Controlled Trials. JAMA 293: 2257-2264 [Abstract] [Full text]  
• Reginster, J. Y., Seeman, E., De Vernejoul, M. C., Adami, S., Compston, J., Phenekos, C., Devogelaer, J. P., Curiel, M. D., Sawicki, A., Goemaere, S., Sorensen, O. H., Felsenberg, D., Meunier, P. J. (2005). Strontium Ranelate Reduces the Risk of Nonvertebral Fractures in Postmenopausal Women with Osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) Study. J. Clin. Endocrinol. Metab. 90: 2816-2822 [Abstract] [Full text]  
• Grey, A., Lucas, J., Horne, A., Gamble, G., Davidson, J. S., Reid, I. R. (2005). Vitamin D Repletion in Patients with Primary Hyperparathyroidism and Coexistent Vitamin D Insufficiency. J. Clin. Endocrinol. Metab. 90: 2122-2126 [Abstract] [Full text]  
• Calvo, M. S, Whiting, S. J, Barton, C. N (2004). Vitamin D fortification in the United States and Canada: current status and data needs. Am. J. Clin. Nutr. 80: 1710S-1716S [Abstract] [Full text]  
• Dawson-Hughes, B. (2004). Racial/ethnic considerations in making recommendations for vitamin D for adult and elderly men and women. Am. J. Clin. Nutr. 80: 1763S-1766S [Abstract] [Full text]  
• Cummings, S., Sellmeyer, D. (2004). Review: calcium supplementation has a small positive effect on bone mineral density but not fractures in postmenopausal women. Evid. Based Med. 9: 170-170 [Full text]  
• Bouxsein, M. L., Kaufman, J., Tosi, L., Cummings, S., Lane, J., Johnell, O. (2004). Recommendations for Optimal Care of the Fragility Fracture Patient to Reduce the Risk of Future Fracture. J Am Acad Orthop Surg 12: 385-395 [Abstract] [Full text]  
• Dietrich, T., Joshipura, K. J, Dawson-Hughes, B., Bischoff-Ferrari, H. A (2004). Association between serum concentrations of 25-hydroxyvitamin D3 and periodontal disease in the US population. Am. J. Clin. Nutr. 80: 108-113 [Abstract] [Full text]  
• Francis, R.M., Baillie, S.P., Chuck, A.J., Crook, P.R., Dunn, N., Fordham, J.N., Kelly, C., Rodgers, A. (2004). Acute and long-term management of patients with vertebral fractures. QJM 97: 63-74 [Abstract] [Full text]  
• Ionescu, A.A., Schoon, E. (2003). Osteoporosis in chronic obstructive pulmonary disease. Eur Respir J 22: 64s-75s [Abstract] [Full text]  
• Grados, F., Brazier, M., Kamel, S., Mathieu, M., Hurtebize, N., Maamer, M., Garabedian, M., Sebert, J.-L., Fardellone, P. (2003). Prediction of Bone Mass Density Variation by Bone Remodeling Markers in Postmenopausal Women with Vitamin D Insufficiency Treated with Calcium and Vitamin D Supplementation. J. Clin. Endocrinol. Metab. 88: 5175-5179 [Abstract] [Full text]  
• Looker, A. C. (2003). Interaction of Science, Consumer Practices and Policy: Calcium and Bone Health as a Case Study. J. Nutr. 133: 1987S-1991 [Abstract] [Full text]  
• Brown, J. P., Josse, R. G. (2003). Lignes directrices de pratique clinique 2002 pour le diagnostic et le traitement de l'osteoporose au Canada. CMAJ 168: SF1-38 [Abstract] [Full text]  
• Feskanich, D., Willett, W. C, Colditz, G. A (2003). Calcium, vitamin D, milk consumption, and hip fractures: a prospective study among postmenopausal women. Am. J. Clin. Nutr. 77: 504-511 [Abstract] [Full text]  
• Brown, J. P., Josse, R. G. (2002). 2002 clinical practice guidelines for the diagnosis and management of osteoporosis in Canada. CMAJ 167: s1-34 [Abstract] [Full text]  
• Tuck, S P, Francis, R M (2002). Osteoporosis. Postgrad. Med. J. 78: 526-532 [Abstract] [Full text]  
• Morley, J. E. (2002). Editorial: A Fall Is a Major Event in the Life of an Older Person. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 57: M492-495 [Full text]  
• Meunier, P. J., Slosman, D. O., Delmas, P. D., Sebert, J. L., Brandi, M. L., Albanese, C., Lorenc, R., Pors-Nielsen, S., De Vernejoul, M. C., Roces, A., Reginster, J. Y. (2002). Strontium Ranelate: Dose-Dependent Effects in Established Postmenopausal Vertebral Osteoporosis--A 2-Year Randomized Placebo Controlled Trial. J. Clin. Endocrinol. Metab. 87: 2060-2066 [Abstract] [Full text]  
• Marcus, R., Wong, M., Heath, H. III, Stock, J. L. (2002). Antiresorptive Treatment of Postmenopausal Osteoporosis: Comparison of Study Designs and Outcomes in Large Clinical Trials with Fracture as an Endpoint. Endocr. Rev. 23: 16-37 [Abstract] [Full text]  
• Wilkin, T. J, Devendra, D., Dequeker, J., Luyten, F. P (2001). For and against: Bone densitometry is not a good predictor of hip fracture For Against. BMJ 323: 795-799 [Full text]  
• Lips, P. (2001). Vitamin D Deficiency and Secondary Hyperparathyroidism in the Elderly: Consequences for Bone Loss and Fractures and Therapeutic Implications. Endocr. Rev. 22: 477-501 [Abstract] [Full text]  
• Reid, D.M., Macdonald, H.M. (2001). Nutrition and bone: is there more to it than just calcium and vitamin D?. QJM 94: 53-56 [Full text]  
• McClung, M. R., Geusens, P., Miller, P. D., Zippel, H., Bensen, W. G., Roux, C., Adami, S., Fogelman, I., Diamond, T., Eastell, R., Meunier, P. J., Wasnich, R. D., Greenwald, M., Kaufman, J.-M., Chesnut, Ph.D. C. H., Reginster, J.-Y. (2001). Effect of Risedronate on the Risk of Hip Fracture in Elderly Women. NEJM 344: 333-340 [Abstract] [Full text]  
• Black, D. M., Thompson, D. E., Bauer, D. C., Ensrud, K., Musliner, T., Hochberg, M. C., Nevitt, M. C., Suryawanshi, S., Cummings, S. R. (2000). Fracture Risk Reduction with Alendronate in Women with Osteoporosis: The Fracture Intervention Trial. J. Clin. Endocrinol. Metab. 85: 4118-4124 [Abstract] [Full text]  
• GEORGE, G. H. M., PATEL, S. (2000). Secondary prevention of hip fracture. Rheumatology (Oxford) 39: 346-349 [Full text]  
• Heaney, R. P. (2000). Calcium, Dairy Products and Osteoporosis. J. Am. Coll. Nutr. 19: 83S-99 [Abstract] [Full text]  
• Ettinger, B., Black, D. M., Mitlak, B. H., Knickerbocker, R. K., Nickelsen, T., Genant, H. K., Christiansen, C., Delmas, P. D., Zanchetta, J. R., Stakkestad, J., Gluer, C. C., Krueger, K., Cohen, F. J., Eckert, S., Ensrud, K. E., Avioli, L. V., Lips, P., Cummings, S. R., for the Multiple Outcomes of Raloxifene Evaluation, (1999). Reduction of Vertebral Fracture Risk in Postmenopausal Women With Osteoporosis Treated With Raloxifene: Results From a 3-Year Randomized Clinical Trial. JAMA 282: 637-645 [Abstract] [Full text]  
• Anderson, F., Cooper, C (1999). The influence of osteoporosis in trauma. Trauma 1: 181-192 [Abstract]  
• Compston, J E (1998). Vitamin D deficiency: time for action. BMJ 317: 1466-1467 [Full text]  
• Storm, D., Porter, R. E. E. S., Musgrave, K., Vereault, D., Patton, C., Kessenich, C., Mohan, S., Chen, T., Holick, M. F., Rosen, C. J. (1998). Calcium Supplementation Prevents Seasonal Bone Loss and Changes in Biochemical Markers of Bone Turnover in Elderly New England Women: A Randomized Placebo-Controlled Trial. J. Clin. Endocrinol. Metab. 83: 3817-3825 [Abstract] [Full text]  
• Thomas, M. K., Lloyd-Jones, D. M., Thadhani, R. I., Shaw, A. C., Deraska, D. J., Kitch, B. T., Vamvakas, E. C., Dick, I. M., Prince, R. L., Finkelstein, J. S. (1998). Hypovitaminosis D in Medical Inpatients. NEJM 338: 777-783 [Abstract] [Full text]  
• Eastell, R. (1998). Treatment of Postmenopausal Osteoporosis. NEJM 338: 736-746 [Full text]  
• Cummings, S. R., Raisz, L. G., Reichert, S. F., Burger, C., Prokop, A., Rehm, K.E., Raaymakers, E. L.F.B., Zuckerman, J. D., Rosenberg, A. D. (1996). Hip Fracture. NEJM 335: 1994-1996 [Full text]  
• Mets, T, Torgerson, D, Campbell, M (1994). Calcium, vitamin D, and hip fractures Incidence of falls may have decreased. BMJ 309: 193-193 [Full text]