Education and debate

Current Issues in Cancer: Multiple myeloma

Department of Immunology, University of Birmingham Medical School, Birmingham B15 2TT Cancer Research Campaign Trials Unit, University of Birmingham Medical School Correspondence to: Professor MacLennan.

Multiple myeloma occurs in over 2000 new patients in England and Wales each year. It presents most frequently as bone pain and patients tend to become dehydrated and may develop renal failure. No available treatment is curative, but about two thirds of patients achieve a stable response with low dose combination chemotherapy. Combination chemotherapy including doxorubicin and carmustine with the alkylating agents cyclophosphamide and melphalan achieve a higher stable response rate than conventional treatment with melphalan and prednisone without additional haematological toxicity. These responses are associated with loss of bone pain and patients remain symptom free for months without further treatment. Relapse occurs on average in a little under two years and, though second responses are frequently obtained, the disease eventually becomes refractory. This paper looks at who should be treated and the benefits that may be expected from the treatments available.

Multiple myeloma is a diffuse . . . [Full text of this article]

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Relevant Article

Multiple myeloma

N H Russel, A E Hunter, A Haynes, and E M Bessell
BMJ 1994 308: 1715. [Extract] [Full Text]

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• Russel, N H, Hunter, A E, Haynes, A, Bessell, E M (1994). Multiple myeloma. BMJ 308: 1715-1715 [Full text]