BMJ 1994;308:787-788 (19 March)
Letters
Bacterial vaginosis and preterm delivery Bacteria may contribute to lung disease in neonates
EDITOR, - Phillip E Hay and colleagues' report on abnormal bacterial colonisation of the genital tract and preterm labour.1 The association between infection and preterm labour has been widely reported, with the genital mycoplasmas (Ureaplasma urealyticum and Mycoplasma hominis) often being implicated.2 Many of the preterm infants need ventilation, and a considerable number develop chronic lung disease. In our unit in 1993 there were 84 survivors of <=30 weeks' gestation, of whom 41 developed chronic lung disease. The aetiology of this disease is multifactorial, with gestation and positive pressure ventilation being the most important determinants.
In a pilot study of the incidence of ureaplasma and mycoplasma infections the endotracheal secretions of all intubated neonates of <=30 weeks' gestation (n=63) were examined weekly from birth while the neonates remained intubated. Sixteen of the infants were positive for one or both organisms, with 11 yielding positive results on the first culture. Fifteen . . . [Full text of this article]

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