BMJ, doi: 10.1136/bmj.39147.604896.55, (Published 20 April 2007)

RESEARCH

Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)

Nancy R Cook ^1*, Jeffrey A Cutler ², Eva Obarzanek ², Julie E Buring ¹, Kathryn M Rexrode ¹, Shiriki K Kumanyika ³, Lawrence J Appel ⁴, Paul K Whelton ⁵

¹ Brigham and Women's Hospital, Harvard Medical School, Boston, MA
² National Heart, Lung, and Blood Institute, Bethesda, MD
³ University of Pennsylvania School of Medicine, Philadelphia, PA
⁴ Johns Hopkins University, Baltimore, MD
⁵ Loyola University Health System, Maywood, IL

^* Correspondence to: ncook{at}rics.bwh.harvard.edu.

Objective To examine the effects of reduction in dietary sodium intake on cardiovascular events using data from two completed randomised trials, TOHP I and TOHP II.

Design Long term follow-up assessed 10-15 years after the original trial.

Setting 10 clinic sites in 1987-90 (TOHP I) and nine sites in 1990-5 (TOHP II). Central follow-up conducted by post and phone.

Participants Adults aged 30-54 years with prehypertension.

Intervention Dietary sodium reduction, including comprehensive education and counselling on reducing intake, for 18 months (TOHP I) or 36-48 months (TOHP II).

Main outcome measure Cardiovascular disease (myocardial infarction, stroke, coronary revascularisation, or cardiovascular death).

Results 744 participants in TOHP I and 2382 in TOHP II were randomised to a sodium reduction intervention or control. Net sodium reductions in the intervention groups were 44 mmol/24 h and 33 mmol/24 h, respectively. Vital status was obtained for all participants and follow-up information on morbidity was obtained from 2415 (77%), with 200 reporting a cardiovascular event. Risk of a cardiovascular event was 25% lower among those in the intervention group (relative risk 0.75, 95% confidence interval 0.57 to 0.99, P=0.04), adjusted for trial, clinic, age, race, and sex, and 30% lower after further adjustment for baseline sodium excretion and weight (0.70, 0.53 to 0.94), with similar results in each trial. In secondary analyses, 67 participants died (0.80, 0.51 to 1.26, P=0.34).

Conclusion Sodium reduction, previously shown to lower blood pressure, may also reduce long term risk of cardiovascular events.

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(Accepted 7 February 2007)
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